Quantitative approach to facilitated diffusion with intersegmental jumping
نویسندگان
چکیده
Michael A. Lomholt, Bram van den Broek, 3 Svenja-Marei J. Kalisch, Gijs J.L. Wuite, and Ralf Metzler MEMPHYS Center for Biomembrane Physics, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark Department of Physics and Astronomy, Faculty of Sciences, VU University, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands Physics of Life Processes, Leiden Institute of Physics, Leiden University, Niels Bohrweg 2, 2333 CA Leiden, The Netherlands Physics Department, Technical University of Munich, D-85747 Garching, Germany (Dated: December 16, 2008)
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Facilitated diffusion with DNA coiling.
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We study a model of protein searching for a target, using facilitated diffusion, on a DNA molecule confined in a finite volume. The model includes three distinct pathways for facilitated diffusion: (a) sliding--in which the protein diffuses along the contour of the DNA, (b) jumping--where the protein travels between two sites along the DNA by three-dimensional diffusion and finally (c) interseg...
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